Second row, division of the human heavy chains into words.
![amino acid sequence amino acid sequence](http://mrsebiology75.weebly.com/uploads/5/1/4/8/5148626/9698672_orig.jpg)
#Amino acid sequence software
We developed a software tool for analysis, classification, and prediction of residues in sequences of the Ig family.įirst row, residues are numbered as in the Kabat database. Our approach allowed us to reconstruct the incomplete human heavy chains in which residues at certain positions at the beginning or end of the chain are known. For every class, an amino acid pattern of an entire sequence (complementarity determining regions excepting) has been determined. It is important to note that it is possible to achieve same six-class classification of the human heavy chains on the basis of a different set of positions found not at the beginning but near the end of the sequence (around position 80). It was shown that a sequence can be assigned to one of six classes depending on which residues are found at its positions 1, 3, 5, 6, 7, 9, 10, 12, and 13. In this paper, results of analysis of 1,172 human heavy chains are presented. Thus, once the class of a sequence is determined, one can predict the residue(s) at almost any position in the sequence.
![amino acid sequence amino acid sequence](http://2.bp.blogspot.com/-p9cRcMlZFhA/VHyU01gYntI/AAAAAAAAReM/8MXnHNBD7yU/s1600/codon%2Bchart.gif)
Sequences within a class follow the same amino acid pattern, i.e., residues at identical positions are, in an overwhelming majority of sequences of that class, identical or chemically related. The defining characteristic of a class is presence of particular residues at several class-determining positions. A new method for classification of Ig sequences is suggested.